Most business ideas fail; however, without a strong experimentation culture and practice, few organizations will be aware of or in a position to change the success rate for their business ideas. Here, Eric Colson, Daragh Sibley, and Dave Spiegel describe how cognitive biases, emergent behaviors, and company growth impact an organization’s ability to generate and implement successful business ideas. They advocate strongly for experimentation and analysis to more objectively measure business and product decisions, as well as systems and processes that enable teams to iterate quickly, thereby testing a greater number of ideas.